COLIZHE®

Description

Mechanism of Action

Colistin is a Polymyxin antibiotic. The mechanism of action of Polymyxins is not yet clearly described. However, it has previously been proven that Colistin causes bacteria death by changing the bacterial membrane permeability. Contrary to many antibiotics that act only during the growth of bacteria, Colistin kills bacteria both in their active and passive stages. Microbial organisms that are sensitive to Colistin develop resistance to it rarely.

Indications of use

It can be used for the prevention and treatment of intestinal infections such as E.coli, Salmonella, and other gram-negative bacteria in poultry. Colistin is not absorbed through the gut and hence yields a high concentration in the gut lumen, exerting more efficacy than many other antibiotics. It can also be used simultaneously with many antibiotics and antibacterials including Erythromycin, Clindamycin, Bacitracin, and Sulfonamides to obtain a synergistic effect.

Dosage and route of administration

Calf and Lamb: 50000 IU per kg body weight every 12 hours in drinking water or replacement feed or 0.25 ml of solution per 10 kg body weight two times daily for 3-4 days.

Poultry: 75000 IU per kg body weight daily or 0.25 ml per liter in drinking water for 3 days.

Storage conditions

Keep away from direct light and under 25° C.

Withdrawal Time

2 days before slaughter in broilers.

Meat and viscera: 7 days

Drug interactions:

None

Precautions

Keep out of reach of children.